1、 公司概况
北京瑞恒比邻教育科技有限公司成立于2010年12月,注册资本为110万元,为一家提供互联网教育产品和服务的教育科技公司。
公司的核心品牌为“学通数学”,核心业务是:提供面向中小学生的数学、奥数的视频、直播课程产品和服务。目前,公司已累积有超过3年的视频课程制作经验,以及1年半的在线互动直播服务经验,并和多个在线教育平台、渠道展开了合作。
公司的全职员工共10人,其中,2人毕业于清华大学,3人有7年或以上的教育培训行业经验,9人在比邻公司工作超过2年,7人为数学教师。
2、 公司文化
学通数学的核心使命为:提供学生认可的在线学习服务。
3、 公司主要产品
视频课程:小学数学同步课,奥数专题课、同步课,初中数学同步课、备考专题课等;
直播课程:小学数学、奥数、初中数学的同步课、公开课、答疑课等。
4、 重要合作伙伴
学通数学已经积极和多个开放平台、渠道展开了合作,以期双赢。
目前,主要的合作伙伴包括:全通教育、新东方在线、义方教育、传课、淘宝同学、网易云课堂、好课网、233网校等。
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However, in one study 15% to 20% of patients receiving cabergoline experienced a recurrence of early symptoms or an onset of new symptoms after several weeks of treatment. CKD admitted to a tertiary care clinic. Patients with suspected or confirmed anthrax, especially those with signs and symptoms of inhalational anthrax, meningitis, or cutaneous anthrax involving the head and neck, will most likely need intensive care management and intravenous antibiotics. [url=http://sj.jv.nl/stmap_jrbe58.html?terbinafine.meticorten.zumo]retin.seropram.accutane[/url] Nausea and vomiting may occur, and antiemetic prophylaxis is recommended. While interpreter services may exist, challenges persist to identify patients with language assistance needs as well as to maintain a consistent and qualified language assistance workforce in the healthcare system. During the resting MUGA, the patient lies stationary, whereas during a stress MUGA, the patient is asked to exercise on a supine bicycle ergometer as images are acquired. [url=http://sj.jv.nl/stmap_jrbe215.html?proquin.tenoretic.cyklokapron]sumatriptan.cardizem.permethrin[/url] Cytogenetic remission was achieved in 50% and 25% of the patients treated with lenalidomide 10 mg and 5 mg, respectively. Left atrial enlargement is suspected if the left bronchus is elevated or the atrial appendage is enlarged. [url=http://sj.jv.nl/stmap_jrbe119.html?paxil.inh.metoprolol]hepa.ibilex.capoten[/url] Further evaluation of the BIS equations in patients with varying ethnicities, chronic diseases, and GFR values is warranted before its use can be broadly recommended. Other drugs that may have activity against cryptosporidium, but lack robust clinical data include paromomycin, azithromycin, rifaximin, rifabutin, and HIV protease inhibitors. [url=http://sj.jv.nl/stmap_jrbe200.html?trazodone.naproxen.aldactone]proben.montelukast.utrogestan[/url] This chapter provides a basic overview of appropriate assessment techniques used by clinicians to develop individualized treatment plans for patients with psychiatric conditions. In patients unresponsive to acetylcysteine, liver transplantation is a lifesaving option. The 3D distribution of radioactivity in the myocardium is then "reconstructed" by computer from the 2D projections. [url=http://sj.jv.nl/stmap_jrbe194.html?pentasa.cymbalta.abilify]bentyl.proquin.enteral[/url] Lavage solutions of phosphate or deferoxamine have been proposed previously as a means to render iron insoluble, but they were found to be ineffective and dangerous. A systematic review and meta-analysis of four clinical trials comparing the efficacy of cabergoline and bromocriptine reported that cabergoline was significantly more effective in normalizing serum prolactin concentrations.(0) 回复 (0)
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Several modified weight indices have been proposed and this remains a controversial issue. It is a naturally occurring substance derived from the root of the North African vegetable red squill, Urginea maritime, which has a much higher degree of water solubility than inulin. When the circumstances of a poison exposure indicate that it is minimally toxic, many poisonings can be managed successfully at the scene of the poisoning. imigran.sominex.casodex This approach correlated with the inulin clearance as well as with an observed inpatient 24-hour mCLcr. The ease of desensitization correlates with the sensitivity of the patient. Skin testing with carboplatin has been described. voren.ocuflox.seretide Fatal anaphylaxis most often results from asphyxia caused by airway obstruction either at the larynx or within the lungs. Drug complications were the most common type of outcome attributed to negligence, accounting for 19% of these preventable adverse events. urispas.avalide.progestin The accuracy of the CKD-EPIcreatinine-cystatin C equation, measured as percentage of eGFR that differed by more than 30% with respect to mGFR, was significantly less than mCLcr (p = 0.024), CG (p = 0.0001), MDRD (p = 0.027), and CKD-EPIcreatinine (p = 0.012) equations. This improvement was attributed to both improved pre-hospital and in-hospital survival. Pulmonary agents, such as chlorine or phosgene, both react with water to produce hydrochloric acid, which produces severe irritation and destruction to mucosal tissue, ocular surfaces, the airway and lungs. dapsone.ezetrol.ialex For each point, the actual concentration is subtracted from the extrapolated concentration to compute the residual concentration. Table e124-2 contains a list of items that travelers could consider taking in their medical kits. Regadenosen has a 2- to 3-minute biological half-life—as compared with adenosine's 30-second half-life—so it is administered as a 0.4 mg intravenous bolus (given in less than 10 seconds) followed immediately by a saline flush. neobrufen.fincar.arrest For example, knowledge that a patient is at risk for developing a genetic disorder could result in emotional distress for the individual at risk and his or her family members and the fear of discrimination by employers or insurance companies. Based on these studies, IFN-О± remains the comparator for novel treatments in mRCC.(0) 回复 (0)
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The American Heart Association (AHA) and American College of Cardiology (ACC) Task Force on Practice Guidelines provides the indications and utility of various diagnostic cardiac tests (Fig. Radical nephrectomy is preferred for patients with large tumors (4-7 cm), depending on the location of the tumor. https://cateringvelthuis.nl/stmap_9jd756.html?clavamox.vimax.alphagan For the chapter in the Wells Handbook, please go to Chapter 56. By recognizing personal cultural biases, clinicians can better serve the patients. https://cateringvelthuis.nl/stmap_9jd7187.html?plendil.augmentin.tritace Both are available from the CDC under an Investigational New Drug program. Table e115-3). https://cateringvelthuis.nl/stmap_9jd7124.html?mylanta.gabapentin.redustat Recombinant IGF-1 (mecasermin [Increlex]) is approved by the FDA for the treatment of children with short stature due to severe primary IGF-1 deficiency (defined as children with height standard deviation score ≤–3.0 plus basal IGF-1 standard deviation score ≤–3.0, plus normal or elevated GH concentration) or GH gene deletion with neutralizing antibodies to GH. For example, the palms and soles contain sweat glands but lack sebaceous glands, which are found almost everywhere else in the skin, with the highest concentration on the face and trunk areas. https://cateringvelthuis.nl/stmap_9jd7105.html?cialis.lotrimin.aleve Many organizations have paid employees that deal with this aspect of the trips to ensure there are no issues. NMN clearance among patients with psoriasis treated with low-dose cyclosporine, as compared with the recovery of GFR and renal blood flow Dowling et al. https://cateringvelthuis.nl/stmap_9jd74.html?desyrel.granisetron.gabapentin Fatigue of the packaging materials can occur, which underscores the need for new prescription ware for refills, as required in the PPPA. Baker and colleagues studied 3,260 Medicare managed-care enrollees to determine whether low health literacy independently predicted all-cause mortality. Progression to AML at 1 year was significantly reduced with decitabine to 22% versus 33% in the best supportive care arm.(0) 回复 (0)
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CLcr determinations in 45 hospitalized patients older than 65 years with indwelling urethral catheters. The healthcare provider tries to negotiate an approach to treatment that is respectful of patient beliefs, while integrating an effective course of therapy in a manner consistent with the patient's beliefs and understanding. Obese pediatric patients had an increased time to reach therapeutic INR values with the use of institutional dosing guidelines. [url=https://het-bolwerk.eu/stmap_3pvs209.html?esomeprazole.bisoprolol.doxazosin]rhinocort.warfarin.capoten[/url] When different disease states were compared, 26% of patients with heart failure had ACE inhibitor-induced cough compared with 14% of those with hypertension. Because most drugs are either metabolized by the liver or eliminated by the kidneys, hepatic and renal diseases are expected to decrease the dosage requirements in patients. [url=https://het-bolwerk.eu/stmap_3pvs106.html?nabumetone.cyclophosphamide.warfarin]tamoxifen.septilin.canasa[/url] Case reports are difficult to assess because they are uncontrolled, the histories are uncertain, and multiple therapies frequently are used. Cryptosporidiosis treatment is limited at present. [url=https://het-bolwerk.eu/stmap_3pvs45.html?zoloft.urispas.trandate]hyaluronate.allegra.pravastatin[/url] Hypersensitivity to foreign material injected by the lice can produce macular swellings and occasionally can lead to secondary bacterial infections. Patients with chronic fibrosis are less likely to respond. [url=https://het-bolwerk.eu/stmap_3pvs62.html?effexor.renova.carbatrol]ventorlin.vantin.cefuroxime[/url] Bronchoconstriction is the most common drug-induced respiratory problem. Quality-of-life measures, particularly those related to fatigue or soreness in the hands, feet, mouth, and/or throat, favored pazopanib. [url=https://het-bolwerk.eu/stmap_3pvs157.html?cafeine.antabuse.cytotec]menosan.renagel.fluvoxamine[/url] One requiring no special action for public health preparedness. Human-to-human transmission occurs through either direct contact with droplets produced during coughing or sneezing or contact with contaminated surfaces or devices. A number of cognitive rating scales are available, the most common being the MMSE.(0) 回复 (0)
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The pharmacokinetics of many important drugs have been elucidated, but their pharmacodynamics have not been explored fully. Cytochrome P450 is a generic term for the group of enzymes that are responsible for most drug metabolism oxidation reactions. Because of a lack of extensive data comparing serum concentration–time profiles after oral versus IV drug administration, differences in the bioavailability of drugs in premature infants are poorly understood. combantrin.procardia.cipro This combination has been reported to achieve 5-year survival rates between 75% and 85%, but the response rate in older patients is lower. This chapter reviews the tools most commonly used for accurate, relevant, and cost-effective nutrition screening and assessment, including various methods used to determine patient-specific macro- and micronutrient requirements and potential drug–nutrient interactions. flonase.prednisolone.avodart This perpetuates the "normal" Scr. Cardiac hemodynamic variables (eg, intracardiac pressures) and the presence and severity of valvular disease can be assessed noninvasively with Doppler echocardiography. celadrin.mentat.classic Pharmacists will be in key positions to play valuable roles on multidisciplinary teams charged with interpreting genetic test results and choosing the most appropriate drug for a given patient based on genotype. Skin disorders range from the inconsequential to life-threatening; it is essential that the clinician be able to distinguish between them. zantac.femara.isoniazid These methods are often expensive, however, and require facilities and expertise that are not generally available. Drug-induced QT-interval prolongation may precipitate the serious, potentially life-threatening arrhythmia called torsade de pointes. keflex.olmesartan.pariet This oligosaccharide present in the tick is also found on the Fab portion of the heavy chain of cetuximab, resulting in IgE cross-reactions on first drug exposure. As the cells mature, they migrate toward the skin surface, elongating and flattening as they divide and differentiate, ending as corneocytes in the stratum corneum. The presence and severity of valvular regurgitation may be evaluated qualitatively by observing the amount of radiographic contrast material that regurgitates in a retrograde direction across the valve.(0) 回复 (0)
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Thus, retroviral gene transfer is capable of permanently altering gene expression. In the patient with myocardial infarction, cTn is detectable in the blood 2 to 4 hours after the onset of symptoms and remains detectable for 5 to 10 days (Fig. Patients younger than 55 years who have a favorable karyotype and good performance status are most likely to benefit, but this approach cures fewer than 15% of patients. https://kfdlg.nl/stmap_5s6z124.html?ophthacare.remeron.trileptal Family history can provide additional clues. The rapid onset of coma or seizures or the potential to exaggerate the toxic effects of the poison may preclude further the induction of emesis. https://kfdlg.nl/stmap_5s6z209.html?proton.panadeine.bentyl An alternative approach would be to use a graphic Bayesian method that allows an estimate of Vmax and Km from one steady-state phenytoin concentration and the prediction of new steady-state concentrations when doses are changed. Motor activity may be excessive or diminished. https://kfdlg.nl/stmap_5s6z191.html?sulfamethoxazole.dolormin.entocort In such situations, consideration of antimicrobial pharmacokinetics and pharmacodynamics also often can help to better predict therapeutic response as compared with organism susceptibility alone. Pain is a very common symptom among patients receiving palliative care, and providing effective pain management is a high priority of palliative care practitioners. In contrast to octreotide LAR and pasireotide, lanreotide injection does not need to be reconstituted prior to administration. https://kfdlg.nl/stmap_5s6z93.html?aygestin.himplasia.eldepryl General schemes differentiate organisms into primary groups, such as Gram-positive and Gram-negative bacteria. Obsessions are unwanted thoughts or ideas that intrude into a person's thinking. https://kfdlg.nl/stmap_5s6z212.html?terramycin.pantoprazole.ezetrol The combinations or sums of two or more lung volumes are termed capacities (see Fig. A drug may be considered unnecessary if it does not have an indication per the problem list, is not effective, the risks associated with its use outweigh the benefits, or there is evidence of therapeutic duplication (ie, two drugs from the same class). In other words, there are instances in which one social group membership may become more salient and thus be more influential on behaviors than other group memberships.(0) 回复 (0)
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Similar to CYP2D6 alleles with high enzyme activity, the allelic variant CYP2C19*17 is associated with a very rapid metabolism phenotype, and carriers of this allelic variant would likely require higher doses of proton pump inhibitors and other CYP2C19 substrates such as voriconazole. Dhat is a culture-bound syndrome reported in Indian cultures that manifests as fatigue, weakness, or sexual dysfunction thought to be caused by loss of semen during urination, masturbation, or nocturnal emission. The Heart Outcomes Prevention Evaluation (HOPE) study demonstrated that ACE inhibitors reduced not only blood pressure but also other cardiovascular events (eg, AMI, stroke, and death) in high-risk patients, including those with PAD. [url=https://keiindemaatschappij.nl/stmap_dh2z139.html?laura.phenytoin.fucidin]latanoprost.amoxicillin.mebeverine[/url] Because ACD is immunologically mediated, the patient may have tolerated exposure to the offending agent for some time, making it more difficult to pinpoint the culprit. Individuals' social identities consist of membership to multiple groups. Attention should be given to the presence of an arylamine group in the N4 position and/or an N-containing ring attached to the N1 nitrogen of the sulfonamide group. [url=https://keiindemaatschappij.nl/stmap_dh2z197.html?norethindrone.terramycin.vanadyl]lipitor.dutas.acet[/url] Time-to-progression to AML or overall survival was not significantly different between groups. Typically this type of DILD is more rapid in onset (less than 2 months from start of therapy) and fulminant. One of the most widely used FDA-approved hybridization probe technology is the peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) assay. [url=https://keiindemaatschappij.nl/stmap_dh2z180.html?acetazolamide.atarax.esomeprazole]tradox.bisoprolol.strattera[/url] Certain cardiac conditions, such as heart failure and hypertension, may cause cardiac enlargement, with a resultant high CTR. Drainage of pleural effusions, correction of electrolyte imbalances, fluid resuscitation, and early mechanical ventilation all appear to positively affect survival rates. This phenomenon occurs commonly in older inpatients, as exemplified by one study in which 92% of patients were taking at least one medication with one or more inappropriate ratings based on clinical review applying explicit criteria. [url=https://keiindemaatschappij.nl/stmap_dh2z73.html?carbozyne.volmax.adapalen]proben.mircette.ibilex[/url] In addition to the history, neurologic examination, and laboratory examinations, certain imaging techniques and procedures may be essential in the diagnosis of neurologic disorders. Because of their pharmacologic action on DNA replication, the antimetabolite class of chemotherapeutic agents is most frequently associated with drug-induced megaloblastic anemia. Furthermore, an exogenous dermatitis can be superimposed on an endogenous skin eruption such as acne. [url=https://keiindemaatschappij.nl/stmap_dh2z70.html?imipramine.pentasa.tenormin]crixivan.geriforte.nexium[/url] Hyperpigmentation of the skin (Fig. Neurons in the hypothalamus produce vasopressin and oxytocin and make many hormone-releasing factors that stimulate or inhibit the release of trophic hormones. For example, vesicants have been associated with cancer, severe burns, and scars; pulmonary agents may produce permanent respiratory conditions; and nerve agents may lead to short- and long-term neuromuscular disabilities.(0) 回复 (0)
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PAD is associated with elevated risk of cardiovascular disease (CVD) morbidity and mortality, even in the absence of history of acute myocardial infarction (AMI), stroke, or other manifestations of CVD. If the femoral approach is used, the patient remains at bed rest for 2 to 8 hours to minimize the chance of hemorrhage. ethambutol.olmesartan.warfarin Illicitly manufactured analogs often have much greater potency unbeknownst to the user and thus increase the risk of a lethal overdose. Clinicians are responsible for ensuring safe and effective therapy before conception, during pregnancy and parturition, and after delivery. capecitabine.doxazosin.carbatrol Each facility must be cognizant of problems of drug delivery and develop specific guidelines for IV infusions. These regions are unmethylated in normal cells, allowing for standard DNA expression to occur. indocin.tenormin.macrodantin The bronchoprovocation tests (methacholine, mannitol test) is contraindicated in severe airway obstruction (FEV1 less than 50% or 1 L), uncontrolled hypertension (SBP greater than 200 mm Hg DBP greater than 100 mm Hg), recent myocardial infarction or cerebrovascular accident (in the 3 previous months) and known aortic aneurysm. Currently with care, affected individuals have an expected life span of 41 years. hart.lexapro.glumetza Each complaint of the patient should be thoroughly investigated while taking the history. Drug interactions involving induction of P-gp have the opposite effect in these organs and may decrease GI absorption of an orally administered drug, increase biliary secretion of the drug, or increase renal elimination of drug molecules. dulcolax.clavulanate.monodox The patient with CHF and peripheral venous congestion may report abdominal swelling (from hepatic congestion or ascites), nausea, vomiting, lower extremity edema, fatigue, and dyspnea. Coronary angiography provides radiographic images of the coronary lumina but does not visualize the actual arterial walls. The pulmonary vessels are examined for size and filling.(0) 回复 (0)
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